Metalaxyl
Active ingredient Especially harmful

Metalaxyl

Description

Mode of action

Metalaxyl is a systemic fungicide belonging to the phenylamide (acylalanine) chemical class. It is quickly absorbed by the green parts of plants and moves acropetally through the xylem, protecting the entire plant structure including new growth from internal fungal attacks.

The primary mechanism of action involves the inhibition of ribosomal RNA synthesis within the pathogen cells. By blocking RNA polymerase activity, the fungicide disrupts the metabolism of the fungus, effectively stopping mycelial growth and inhibiting the production of spores.

Due to its systemic nature, metalaxyl provides excellent curative and protective properties. It can halt the development of fungal infections if applied shortly after the initial colonization of plant tissues by the pathogen.

The high mobility of metalaxyl within the plant makes it particularly effective during periods of rapid crop development. It reaches and protects critical plant tissues faster than many contact-based fungicides, ensuring a robust defense against aggressive diseases.

Because fungal pathogens can develop resistance to phenylamides, metalaxyl is typically formulated in mixtures with contact fungicides. These combinations enhance efficacy and broaden the spectrum of controlled diseases while managing resistance.

What it targets

Metalaxyl is highly targeted towards the control of oomycetes. It is widely used to manage diseases such as late blight (Phytophthora), downy mildew, and various root and crown rots that affect a vast range of crops.

Key crops protected by this substance include potatoes, tomatoes, cucumbers, onions, vines, and sunflowers. It is also extensively used for seed treatment to prevent soil-borne pathogens from damaging emerging seedlings.

Rates and timing

Dosage rates for metalaxyl products depend on the specific formulation, the crop being treated, and the severity of the disease pressure. Application rates generally range from 0.5 to 2.5 kg of active ingredient per hectare.

Timing of application is crucial and should be aligned with the plant growth stage and regional disease forecasting models. Preventive applications are highly recommended, with subsequent treatments spaced according to label instructions and local environmental conditions.

Restrictions

Metalaxyl is generally classified as having low to moderate toxicity to humans but requires careful handling. Users must wear appropriate personal protective equipment, including gloves, goggles, and respiratory masks, to prevent skin and respiratory exposure.

The fungicide can pose risks to aquatic organisms; therefore, application near water bodies should be strictly prohibited. Furthermore, growers must adhere to resistance management strategies by rotating metalaxyl with fungicides of different modes of action to maintain its long-term efficacy.

Regulatory

Status in the European Union

Approved in the EU

CAS number
57837-19-1
Approved from
01.07.2010
Approval until
30.09.2026
ADI
0.08 mg/kg bw/day
ARfD
0.5 mg/kg bw
AOEL
0.08 mg/kg bw/day
Hazard classification (CLP)
Acute Tox. 4 - H302Aquatic Chronic 3 - H412Skin Sens. 1 - H317

EU status is for reference only and does not replace national registration in your country.

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